Short-Chain Acyl-CoA Dehydrogenase (SCAD)



Short-chain acyl-CoA dehydrogenase deficiency (SCAD) is a condition in which the body is unable to break down certain fats.  Most individuals who are identified as having SCAD never experience symptoms, while some individuals experience serious health effects. In babies, the signs of SCAD include sleeping longer or more often, behavior changes, irritable mood, poor appetite, fever, diarrhea, vomiting, trouble breathing, seizures (epilepsy), delayed growth and weight gain, developmental delays, hyperactivity, weak muscle tone, small head size, and low blood sugar. Detecting the condition early and beginning treatment may help prevent many of the serious outcomes of SCAD. 

Condition Type:



Short-chain acyl-CoA dehydrogenase (SCAD) is estimated to affect 1 in 40,000 to 100,000 newborns.

More Information for Parents:
Also known as:
  • SCADH deficiency
  • ACADS deficiency
  • Short-chain acyl-CoA dehydrogenase deficiency
  • Short-chain acyl-coenzyme A dehydrogenase deficiency
  • Lipid-storage myopathy secondary to short-chain acyl-CoA dehydrogenase deficiency

Core Conditions