About
Short-chain acyl-CoA dehydrogenase deficiency (SCAD) is a condition in which the body is unable to break down certain fats. Most individuals who are identified as having SCAD never experience symptoms, while some individuals experience serious health effects. In babies, the signs of SCAD include sleeping longer or more often, behavior changes, irritable mood, poor appetite, fever, diarrhea, vomiting, trouble breathing, seizures (epilepsy), delayed growth and weight gain, developmental delays, hyperactivity, weak muscle tone, small head size, and low blood sugar. Detecting the condition early and beginning treatment may help prevent many of the serious outcomes of SCAD.
Condition Type:
Secondary
Frequency:
Short-chain acyl-CoA dehydrogenase (SCAD) is estimated to affect 1 in 40,000 to 100,000 newborns.
More Information for Parents:
Also known as:
- SCADD
- SCADH deficiency
- ACADS deficiency
- Short-chain acyl-CoA dehydrogenase deficiency
- Short-chain acyl-coenzyme A dehydrogenase deficiency
- Lipid-storage myopathy secondary to short-chain acyl-CoA dehydrogenase deficiency
Core Conditions
- Propionic Acidemia (PROP)
- Methylmalonic Acidemia (Methylmalonyl-CoA Mutase Deficiency) (MUT)
- Methylmalonic Acidemia (Cobalamin Conditions)
- Isovaleric Acidemia (IVA)
- 3-Methylcrotonyl-CoA Carboxylase Deficiency (3-MCC)
- 3-Hydroxy-3-Methylglutaric Aciduria (HMG)
- Holocarboxylase Synthetase Deficiency (MCD)
- Beta-Ketothiolase Deficiency (BKT)
- Glutaric Acidemia, Type I (GA-1)
- Mucopolysaccharidosis, Type II (MPS II)
- Biotinidase Deficiency (BIOT)
- Critical Congenital Heart Disease (CCHD)
- Cystic Fibrosis (CF)
- Classic Galactosemia (GALT)
- Hearing Loss or Varying Hearing Levels
- Severe Combined Immunodeficiency (SCID)
- X-Linked Adrenoleukodystrophy (X-ALD)
- Pompe
- Spinal Muscular Atrophy (SMA)
- Mucopolysaccharidosis, Type I (MPS I)
Secondary
- Citrullinemia, Type II (CIT II)
- Hypermethioninemia (MET)
- Benign Hyperphenylalaninemia (H-PHE)
- Biopterin Defect in Cofactor Biosynthesis (BIOPT-BS)
- Biopterin Defect in Cofactor Regeneration (BIOPT-REG)
- Ornithine Transcarbamylase Deficiency (OTC)
- Carbamoyl Phosphate Synthetase Deficiency (CPS)
- Tyrosinemia, Type II (TYR II)
- Tyrosinemia, Type III (TYR III)