About
Severe combined immunodeficiency (SCID) is an inherited immunodeficiency condition in which the body is unable to fight off serious and life-threatening infections. The body’s immune system is made up of different parts that work together to keep the body from getting sick. In a baby with SCID, certain parts of the immune system do not work properly. This puts the baby at risk of getting many infections. Babies who do not get treatment for SCID rarely live past age 2. However, babies with SCID who are treated before getting infections live longer and healthier lives. Early signs of SCID include high number of infections, infections that do not improve with antibiotic treatment for two or more months, diarrhea, poor weight gain or growth (failure to thrive), and thrush (a fungal infection) in the mouth or throat that does not go away.
Condition Type:
Core Conditions
Frequency:
Severe combined immunodeficiency (SCID) occurs in 1 out of every 40,000-75,000 births.
More Information for Parents:
Also known as:
- Severe combined immunodeficiency disorder
- Bubble boy syndrome
Core Conditions
- Propionic Acidemia (PROP)
- Methylmalonic Acidemia (Methylmalonyl-CoA Mutase Deficiency) (MUT)
- Methylmalonic Acidemia (Cobalamin Conditions)
- Isovaleric Acidemia (IVA)
- 3-Methylcrotonyl-CoA Carboxylase Deficiency (3-MCC)
- 3-Hydroxy-3-Methylglutaric Aciduria (HMG)
- Holocarboxylase Synthetase Deficiency (MCD)
- Beta-Ketothiolase Deficiency (BKT)
- Glutaric Acidemia, Type I (GA-1)
- Biotinidase Deficiency (BIOT)
- Critical Congenital Heart Disease (CCHD)
- Cystic Fibrosis (CF)
- Classic Galactosemia (GALT)
- Hearing Loss or Varying Hearing Levels
- Severe Combined Immunodeficiency (SCID)
- X-Linked Adrenoleukodystrophy (X-ALD)
- Pompe
- Spinal Muscular Atrophy (SMA)
- Mucopolysaccharidosis, Type I (MPS I)
Secondary
- Citrullinemia, Type II (CIT II)
- Hypermethioninemia (MET)
- Benign Hyperphenylalaninemia (H-PHE)
- Biopterin Defect in Cofactor Biosynthesis (BIOPT-BS)
- Biopterin Defect in Cofactor Regeneration (BIOPT-REG)
- Ornithine Transcarbamylase Deficiency (OTC)
- Carbamoyl Phosphate Synthetase Deficiency (CPS)
- Tyrosinemia, Type II (TYR II)
- Tyrosinemia, Type III (TYR III)