Glutaric Acidemia, Type II (GA-2)



Glutaric acidemia, type II (GA-2) is a condition in which the body is unable to break down certain fats and proteins.  People affected with GA-2 are unable to convert some of the fats and proteins eaten into energy the body needs to function. This causes too many unused fatty acids and other harmful substances to build up in the body. Signs of GA-2 can begin shortly after birth, in childhood, or even adulthood. Signs of GA-2 include sleeping longer or more often, behavior changes, irritability, weak muscle tone, poor appetite, fever, vomiting, diarrhea, low blood sugar, trouble breathing, sweaty feet smell, seizures (epilepsy), and birth defects. Detecting the condition early and beginning treatment can often prevent the severe outcomes of GA-2. 

Condition Type:



Glutaric acidemia type II (GA-2) is a very rare condition. The exact number of individuals affected by this condition is unknown.

More Information for Parents:
Also known as:
  • GA-2
  • EMA
  • ETFA
  • ETFB
  • ETFDH deficiency
  • Type II
  • MAD
  • MADD
  • Electron transfer flavoprotein deficiency
  • Multiple acyl-CoA dehydrogenase deficiency
  • Multiple FAD dehydrogenase deficiency

Core Conditions