About
Glutaric acidemia, type II (GA-2) is a condition in which the body is unable to break down certain fats and proteins. People affected with GA-2 are unable to convert some of the fats and proteins eaten into energy the body needs to function. This causes too many unused fatty acids and other harmful substances to build up in the body. Signs of GA-2 can begin shortly after birth, in childhood, or even adulthood. Signs of GA-2 include sleeping longer or more often, behavior changes, irritability, weak muscle tone, poor appetite, fever, vomiting, diarrhea, low blood sugar, trouble breathing, sweaty feet smell, seizures (epilepsy), and birth defects. Detecting the condition early and beginning treatment can often prevent the severe outcomes of GA-2.
Condition Type:
Secondary
Frequency:
Glutaric acidemia type II (GA-2) is a very rare condition. The exact number of individuals affected by this condition is unknown.
More Information for Parents:
Also known as:
- GA-2
- EMA
- ETFA
- ETFB
- ETFDH deficiency
- Type II
- MAD
- MADD
- Electron transfer flavoprotein deficiency
- Multiple acyl-CoA dehydrogenase deficiency
- Multiple FAD dehydrogenase deficiency
Core Conditions
- Propionic Acidemia (PROP)
- Methylmalonic Acidemia (Methylmalonyl-CoA Mutase Deficiency) (MUT)
- Methylmalonic Acidemia (Cobalamin Conditions)
- Isovaleric Acidemia (IVA)
- 3-Methylcrotonyl-CoA Carboxylase Deficiency (3-MCC)
- 3-Hydroxy-3-Methylglutaric Aciduria (HMG)
- Holocarboxylase Synthetase Deficiency (MCD)
- Beta-Ketothiolase Deficiency (BKT)
- Glutaric Acidemia, Type I (GA-1)
- Biotinidase Deficiency (BIOT)
- Critical Congenital Heart Disease (CCHD)
- Cystic Fibrosis (CF)
- Classic Galactosemia (GALT)
- Hearing Loss or Varying Hearing Levels
- Severe Combined Immunodeficiency (SCID)
- X-Linked Adrenoleukodystrophy (X-ALD)
- Pompe
- Spinal Muscular Atrophy (SMA)
- Mucopolysaccharidosis, Type I (MPS I)
Secondary
- Citrullinemia, Type II (CIT II)
- Hypermethioninemia (MET)
- Benign Hyperphenylalaninemia (H-PHE)
- Biopterin Defect in Cofactor Biosynthesis (BIOPT-BS)
- Biopterin Defect in Cofactor Regeneration (BIOPT-REG)
- Ornithine Transcarbamylase Deficiency (OTC)
- Carbamoyl Phosphate Synthetase Deficiency (CPS)
- Tyrosinemia, Type II (TYR II)
- Tyrosinemia, Type III (TYR III)