2-Methylbutyrylglycinuria (2MGB)



2-methylbutyrylglycinuria (2MBG) is an inherited condition in which the body is unable to break down certain proteins, which can lead to a harmful amount of organic acids and toxins in the body. Signs of 2MBG often begin at infancy, sometimes as early as a few days after birth. In other cases, signs do not develop until childhood.  Signs of 2MBG include poor appetite, sleeping longer or more often, tiredness, irritability, fever, vomiting, weak muscle tone, delayed growth, tight muscles, and developmental delays. Many of these signs may occur when a baby eats foods that the body cannot break down.

Condition Type:



2-methylbutyrylglycinuria (2MBG) is very rare in the United States. This condition is estimated to occur in every 1 out of 250 to 500 people of Hmong ancestry.

More Information for Parents:
Also known as:
  • 2MBG
  • 2-methylbutyrylglycinuria
  • 2-MBCD deficiency
  • 2-MBAD deficiency
  • Short/branched chain Acyl-CoA dehydrogenase deficiency (SBCAD)

Core Conditions