About
Tyrosinemia, type III (TYR III) is an inherited condition in which the body is unable to break down certain building blocks of proteins, known as amino acids. People with tyrosinemia, type III are unable to break down an amino acid known as tyrosine. This condition can result in learning problems, seizures, and loss of balance if untreated. There are three types of tyrosinemia (I, II, and III); TYR III is the least common type, with fewer than 20 reported cases. Signs of TYR III are highly variable and not well known and may include poor coordination and balance or seizures. These signs may occur when a baby eats foods that the body cannot break down.
Condition Type:
Secondary
Frequency:
Tyrosinemia, type III (TYR III) is a very rare condition. Only a few cases have ever been reported.
More Information for Parents:
Also known as:
- TYR III
- Tyrosinemia due to 4-hydroxyphenylpyruvate dioxygenase deficiency
- Tyrosinemia due to 4-hydroxyphenylpyruvic acid oxidase deficiency
- Tyrosinemia due to HPD deficiency
- Tyrosinemia type III
Core Conditions
- Propionic Acidemia (PROP)
- Methylmalonic Acidemia (Methylmalonyl-CoA Mutase Deficiency) (MUT)
- Methylmalonic Acidemia (Cobalamin Conditions)
- Isovaleric Acidemia (IVA)
- 3-Methylcrotonyl-CoA Carboxylase Deficiency (3-MCC)
- 3-Hydroxy-3-Methylglutaric Aciduria (HMG)
- Holocarboxylase Synthetase Deficiency (MCD)
- Beta-Ketothiolase Deficiency (BKT)
- Glutaric Acidemia, Type I (GA-1)
- Mucopolysaccharidosis, Type II (MPS II)
- Biotinidase Deficiency (BIOT)
- Critical Congenital Heart Disease (CCHD)
- Cystic Fibrosis (CF)
- Classic Galactosemia (GALT)
- Hearing Loss or Varying Hearing Levels
- Severe Combined Immunodeficiency (SCID)
- X-Linked Adrenoleukodystrophy (X-ALD)
- Pompe
- Spinal Muscular Atrophy (SMA)
- Mucopolysaccharidosis, Type I (MPS I)
Secondary
- Citrullinemia, Type II (CIT II)
- Hypermethioninemia (MET)
- Benign Hyperphenylalaninemia (H-PHE)
- Biopterin Defect in Cofactor Biosynthesis (BIOPT-BS)
- Biopterin Defect in Cofactor Regeneration (BIOPT-REG)
- Ornithine Transcarbamylase Deficiency (OTC)
- Carbamoyl Phosphate Synthetase Deficiency (CPS)
- Tyrosinemia, Type II (TYR II)
- Tyrosinemia, Type III (TYR III)